13-P080 Hedgehog signalling in lung development
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چکیده
منابع مشابه
13-P080 Hedgehog signalling in lung development
These are consistent with proposals that Fgf10 expression in the developing sensory tissues is required to induce non-sensory development. To determine the otic epithelial functions of Fgf3 and Fgf10, we generated double conditional mutants using TgPax2Cre, and found that as expected, both genes play roles in semicircular canal morphogenesis. Unexpectedly, these genes also appear to have redund...
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The hedgehog (Hh) pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue and cellular properties such as patterning fields of cells or regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review, we provide an update on recent findings in the field of vertebrate Hh signalling and also d...
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The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to reg...
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The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extend...
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The optic chiasm is an important midline choice point where retinal ganglion cell (RGC) axons from each eye diverge to targets on both sides of the brain, setting up binocular vision. While several cues essential for guidance at the optic chiasm have been identified, it is clear other signals are required. We have begun to investigate the role of the highly related homophilic cell adhesion mole...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.553